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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
TP1528 | Angiotensin I/II (1-5) | Angiotensin I/II 1-5 | RAAS , Others |
Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II. | |||
TP1579 | Angiotensin I/II (1-6) | Angiotensin I/II 1-6 | RAAS , Others |
Angiotensin I/II (1-6) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS) that contains the amino acids 1-6 and is converted from Angiotensin I/II peptide. | |||
T7577 | Angiotensin III, human, mouse | Angiotensin III, human, mouse(3TFA) | RAAS |
Angiotensin III, human, mouse (Angiotensin III, human, mouse(3TFA))(3TFA) is an endogenous angiotensin II receptor (AT2R) agonist(IC50s of 0.648 nM). | |||
T7339 | Angiotensin (1-7) | Ang-(1-7),Angiotensin 1-7,ASP-ARG-VAL-TYR-ILE-HIS-PRO | RAAS , Endogenous Metabolite |
Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) , inhibits purified canine ACE activity (IC50=0.65 μM) with vasodilator and antiproliferative activiti... | |||
T8560 | Angiotensin II human acetate | Ang II acetate,DRVYIHPF acetate,Angiotensin II acetate | Apoptosis , RAAS |
Angiotensin II human acetate (DRVYIHPF acetate) is a vasoconstrictor that mainly acts on the AT1 receptor. | |||
TP1929L1 | Saralasin acetate(34273-10-4 free base) | RAAS | |
Saralasin acetate is a Non-selective angiotensin II antagonist. | |||
T3178 | BIBS 39 | RAAS | |
BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. | |||
T2531 | Eprosartan Mesylate | SKF-108566J | RAAS |
Eprosartan Mesylate (SKF-108566J) is a competitive and reversible Angiotensin II Receptor Blocker. | |||
T7354 | H-Val-Pro-Pro-OH | RAAS | |
H-Val-Pro-Pro-OH is an inhibitor of Angiotensin I converting enzyme (ACE)( IC50 : 9 μM). | |||
T1461 | Candesartan | CV 11974 | RAAS |
Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure. | |||
T22344 | Icatibant Acetate | Bradykinin Receptor | |
Icatibant Acetate, an antagonist of the bradykinin B2 receptor, is used in the treatment of hereditary angioedema. | |||
T13376 | YS-49 | RAAS , Akt , PI3K , Adrenergic Receptor | |
YS-49 is an activator of PI3K/Akt (a downstream target of RhoA). | |||
T5355 | Sparsentan | RE-021,DARA-a | RAAS , Endothelin Receptor |
Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM, respectively) | |||
T6067 | PD 123319 | (S)-(+)-PD 123319,PD123319 | RAAS |
PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist. | |||
T1570 | Telmisartan | BIBR 277 | RAAS , Autophagy |
Telmisartan (BIBR 277) is an Angiotensin 2 Receptor Blocker. The mechanism of action of telmisartan is as an Angiotensin 2 Receptor Antagonist. | |||
T0215L | Losartan | DuP-753 | RAAS |
Losartan (DuP-753) is an angiotensin II receptor antagonist. | |||
T7797 | Tasosartan | WAY-ANA 756 | RAAS |
Tasosartan (WAY-ANA 756) is an antagonist of angiotensin II type 2 (AT2) receptor (IC50 = 1.2 nM). | |||
T6219 | Azilsartan Medoxomil | TAK-491 | RAAS |
Azilsartan Medoxomil (TAK-491) is an orally administered angiotensin II receptor type 1 antagonist with IC50 of 0.62 nM, which used in the treatment of adults with essential hypertension. | |||
T3461 | Losartan Carboxylic Acid | EXP-3174,E-3174 | RAAS |
Losartan Carboxylic Acid (E-3174) a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation. Losartan Carboxylic Acid , a metabolite of losartan, is more potent than l... | |||
T2318 | Sacubitril/Valsartan | Sacubitril mixture with Valsartan,Valsartan,Sacubitril,LCZ696 | Apoptosis , RAAS , Neprilysin |
Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure. | |||
T1518 | Olmesartan Medoxomil | CS 866,Benicar | RAAS |
Olmesartan Medoxomil (Benicar) is an angiotensin II type 1 receptor blocker that is used to manage hypertension. | |||
T2322 | Fimasartan | BR-A-657,Kanarb | Apoptosis , RAAS |
Fimasartan (BR-A-657) is a non-peptide angiotensin II receptor antagonist (ARB) used for the treatment of hypertension and heart failure. Concurrent administration of fimasartan with diuretic hydrochlorothiazide has show... | |||
T4431 | Olodanrigan | PD-126055,EMA401 | RAAS |
Olodanrigan (EMA401), a highly selective AT2R antagonist, inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons. EMA... | |||
T5964 | Olmesartan | CS 088,RNH 6270 | RAAS |
Olmesartan (RNH 6270) is an Angiotensin II Type I receptor antagonist. Olmesartan is the active form of the antihypertensive drug olmesartan medoxomil,and has antihypertensive activity. | |||
T2270 | Trans-Tranilast | Tranilast trans- | RAAS |
Trans-Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993.... | |||
T2400 | Candesartan Cilexetil | TCV-116 | Apoptosis , RAAS |
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor antagonist (IC50: 0.26 nM). After hydrolysis of candesartan cilexetil to candesartan during gastrointestinal absorption, candesartan selectively competes with... | |||
T5824 | Angiotensin II (3-8), human | Angiotensin IV | RAAS |
Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor. | |||
T6716 | Valsartan | Diovan,Tareg,CGP 48933 | RAAS |
Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension. | |||
T7575 | [Sar1, Ile8]-Angiotensin II | [Sar1, Ile8]-Angiotensin II(3TFA) | RAAS , Others |
[Sar1, Ile8]-Angiotensin II(3TFA) is a peptide that has multiple effects on vascular smooth muscle. | |||
T1057 | Azilsartan | TAK-536 | RAAS |
Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres... | |||
T2690 | Tranilast | MK 341,SB 252218 | RAAS , Prostaglandin Receptor |
Tranilast (SB 252218), an antiallergic drug, suppresses lipid mediator and cytokine release from inflammatory cells, therefore utilized in the treatment of allergic disorders. | |||
T19930 | Nitrosoglutathione | S-Nitrosoglutathione,SNOG,Glutathione thionitrite,GSNO | RAAS , NO Synthase |
Nitrosoglutathione (GSNO) is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins. GSNO, an exogenous NO donor and substrate of rat alcohol dehydrogenase class III isoenzyme, i... | |||
T1615 | Irbesartan | SR-47436,BMS-186295 | Apoptosis , RAAS |
Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist. | |||
T0215 | Losartan potassium | DuP-753 potassium,MK 954,DuP 753 | RAAS |
Losartan potassium (DuP-753 potassium) , an Angiotensin II Receptor Blocker, selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. | |||
T7616 | A 779 | RAAS | |
A 779 is a potent antagonist of the G-protein-coupled receptor Mas, the Ang1-7 receptor, which is distinct from conventional AngII. | |||
TP1017L | Angiotensin II 5-valine TFA | Angiotensin II 5-valine TFA(58-49-1 free base) | RAAS |
Angiotensin II 5-valine TFA is an agonist of angiotensin receptor. | |||
T13390 | ZD 7155 hydrochloride | RAAS | |
ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist. | |||
T7743 | ANGIOTENSIN IV TFA(12676-15-2(free base)) | RAAS | |
ANGIOTENSIN IV TFA is a less effective agonist at the angiotensin AT1 receptor. | |||
T28540 | Ripisartan | UP 269-6,UP-2696,UP 2696,UP-269-6,UP269-6 | RAAS |
Ripisartan (UP-269-6) is a potent and specific angiotensin II receptor antagonist that inhibits angiotensin II-mediated sympathetic tachycardia responses. | |||
T40220L | TRV055 acetate | TRV055 acetate (25849-90-5 Free base) | RAAS |
TRV055 acetate is a ligand of angiotensin II type 1 receptor and stimulates cellular Gq-mediated signaling. | |||
T14942 | CGP48369 | RAAS | |
CGP48369 is a potent angiotensin II receptor antagonist with antihypertensive effects that enhances endothelium-dependent relaxation of coronary arteries in spontaneously hypertensive rats. | |||
T14337 | Buloxibutid | AT2 receptor agonist C21 | RAAS |
Buloxibutid (AT2 receptor agonist C21) is a novel and selective small molecule angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and 10 μM for AT2 and AT1 receptors, respectively. | |||
T24588 | Palatrigine | BW-A 256C,BW A256C | Adrenergic Receptor , Angiotensin-converting Enzyme (ACE) |
Palatrigine (BW-A 256C) is a compound with angiotensin-converting enzyme inhibitory and beta-adrenergic receptor blocking properties. | |||
T7616L | A 779 TFA(159432-28-7 free base) | A 779 3TFA(159432-28-7(free base)) | RAAS |
A 779 TFA is a potent antagonist of angiotensin-(1-7) receptor. | |||
T67848 | Valsartan Methyl Ester | RAAS | |
Valsartan Methyl Ester is a potent angiotensin II receptor antagonist, IC50= 0.06uM. | |||
T35834L | (Sar¹)-Angiotensin II acetate | RAAS | |
(Sar¹)-Angiotensin II acetate, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. It binds to brain membrane-rich particles, with a Kd of 2.7 nM. It can stimulate protein synthesis and cell... | |||
T27762 | L-162,313 | L-162313,L 162,313,L162,313 | RAAS |
L-162,313 is an ANG II receptor agonist, a nonpeptide that mimics the biological actions of angiotensin II and induces an increase in MAP. | |||
T28437 | Pomisartan | BIBR-363,BIBR 363,BIBR363 | RAAS |
Pomisartan (BIBR-363) is a small molecule angiotensin type 1 receptor (AT1R) antagonist that is used in the treatment of cardiovascular disease, studying heart failure and hypertensio | |||
T2531L | Eprosartan | KF-108566J free base,Teveten | RAAS |
Eprosartan (SKF-108566J free base) is a selective and competitive nonpeptide angiotensin II receptor antagonist with high affinity for AT1 receptor subtypes and can be used as an antihypertensive agent.Eprosartan has an ... | |||
T65740 | Trityl candesartan | ||
Trityl candesartan is a crucial intermediate used in the synthesis of Candesartan and Candesartan cilexetil, which are angiotensin II receptor antagonists. |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T7040 | Angiotensin II human | DRVYIHPF,Angiotensin II,Hypertensin II,Ang II | Apoptosis , RAAS |
Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthes... | |||
T5S0106 | Peimisine | Ebeiensine | RAAS , AChR |
1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Pe... | |||
T2836 | Isorhamnetin | 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin | MEK , PI3K , Endogenous Metabolite |
Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD... | |||
T37298 | Spinacine | Endogenous Metabolite | |
Spinacine has been isolated from spinach and the roots of Panax ginseng. This conformationally constrained amino acid is a structural element in certain biologically active compounds as glucagon antagonists and angiotens... | |||
T38593 | 1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone | ||
Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9, a quinolone alkaloid derived from Evodia rutaecarpa, is a potent antagonist of the angiotensin II receptor, displaying an IC50 value of 48.2 μM. | |||
TN4860 | Pueroside B | COX , PPAR | |
Pueroside B may can treat coronary heart disease, it can interact with two or more targets[peroxisome proliferator activated receptor γ (PPAR-γ), angiotensin-converting enzyme (ACE), hydroxymethylglutaryl coenzyme A rece... | |||
TN1061 | Ganoderol B | Androgen Receptor | |
Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy throu... | |||
T75697 | 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone | ||
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, exhibits IC50 values of 20.1 μM and 34.1 μM, respectively. Additionally, it demonstr... |
カタログ番号 | 製品名 | Species | Expression System |
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TMPH-02268 | AGTR2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. | |||
TMPH-02267 | AGTRAP Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decr... | |||
TMPY-02869 | MMP-12 Protein, Human, Recombinant (catalytic domain) | Human | E. coli |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPK-00913 | SARS Spike S1 Protein (His & Avi), Biotinylated | SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00439 | SARS-COV-2 Spike RBD Protein (His & Avi), Biotinylated | SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00433 | SARS-COV-2 Spike S1 Protein (hFc & Avi), Biotinylated | SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00434 | SARS-COV-2 Spike RBD Protein (hFc & Avi), Biotinylated | SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00908 | SARS Spike S1 Protein (hFc & Avi) | SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00438 | SARS-COV-2 Spike S Trimer Protein (His & Avi) | SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00444 | SARS-COV-2 Spike S1 NTD Protein (His & Flag) | SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00911 | SARS Spike RBD Protein (His & Avi) | SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00440 | SARS-COV-2 Spike S1 Protein (His & Avi), Biotinylated | SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00437 | SARS-COV-2 Spike RBD Protein (His & Avi) | SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00909 | SARS Spike S1 Protein (hFc & Avi), Biotinylated | SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00912 | SARS Spike RBD Protein (His & Avi), Biotinylated | SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00910 | SARS Spike S1 Protein (His & Avi) | SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00432 | SARS-COV-2 Spike S1 Protein (hFc & Avi) | SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00443 | SARS-COV-2 (Omicron B.1.1.529) Spike S1 Protein (His & Avi), Biotinylated | SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00442 | SARS-COV-2 (Omicron B.1.1.529) Spike S Trimer Protein (His & Avi), Biotinylated | SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPK-00441 | SARS-COV-2 Spike S Trimer Protein (His & Avi), Biotinylated | SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays k... | |||
TMPY-06885 | SARS-CoV-2 XBB.1.16 (Omicron) Spike S1+S2 trimer Protein (ECD, His) | ||
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4;... | |||
TMPH-02274 | JAK2 Protein, Human, Recombinant (His) | Human | E. coli |
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cyto... |
カタログ番号 | 製品名 | ||
---|---|---|---|
L7110 | Anti-Hypertension Compound Library | 678 compounds | |
678 hypertension-related small molecules for high-throughput and high-content screening. |